| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804173 | Biochimie | 2012 | 10 Pages |
Abstract
⺠HisGCg is indispensable for histidine biosynthesis in Corynebacterium glutamicum. ⺠Alkaline pH decreases the inhibitory effect of histidine. ⺠Asn215, Leu231, and Thr235 in the C domain are critical for histidine binding. ⺠The change of electrostatic potential of HisGCg results in releasing allosteric inhibition.
Keywords
PRPPkDaPPPPDBMALDI-TOFDTT5-phosphoribosyl 1-pyrophosphateAsparaginealanineSDS-PAGEthreoninebase pairsdithiothreitolcircular dichroismPhenylalanineLeucineLysinematrix-assisted laser desorption/ionization time of flightpentose phosphate pathwayFeedback inhibitionMutagenesishistidinepolymerase chain reactionPCRProtein Data BankCorynebacterium glutamicumKilo Dalton
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Yun Zhang, Xiuling Shang, Aihua Deng, Xin Chai, Shujuan Lai, Guoqiang Zhang, Tingyi Wen,