Article ID Journal Published Year Pages File Type
10804193 Biochimie 2011 7 Pages PDF
Abstract
► Effect of UNA modifications in a model quadruplex has been studied. ► UNA modifications cause structural transitions in the G- quadruplex studied. ► UNA in loop stabilizes G-quadruplex but in the stem it destabilizes the structure. ► All the sequences are stable at 37 °C. ► UNA confers greater biostability on the oligonucleotides.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Unlocking G-quadruplex: Effect of unlocked nucleic acid on G-quadruplex stability
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