| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804195 | Biochimie | 2011 | 10 Pages |
Abstract
⺠We examine the mechanism of pH & calcium induced M-ficolin (a FREP):CRP interaction. ⺠We find the C-terminus of M-ficolin FBG domain to be pH and calcium-sensitive. ⺠Stronger interaction between M-ficolin FBG:CRP occurs under pH 6.5 and 2 mM Ca2+. ⺠We observe that CRP binds to the pH and calcium-sensitive C-terminus of FBG. ⺠Low pH and low calcium induce FBG:CRP interaction via H284.
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Authors
Jing Zhang, Lifeng Yang, Ganesh Srinivasan Anand, Bow Ho, Jeak Ling Ding,