| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804206 | Biochimie | 2011 | 7 Pages |
Abstract
⺠Leptin resistance develops spontaneously in particular tissues during adult life. ⺠In the liver desensitization develops for the STAT3 but not for the Akt pathway. ⺠In adipose tissue desensitization concerns both STAT3 and Akt pathways. ⺠In the heart both STAT3 and Akt pathways keep full leptin responsiveness during adult life. ⺠The integrity of the STAT3 pathway is necessary to prevent hepatic steatosis.
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Authors
Paula Stucchi, RocÃo Guzmán-Ruiz, Marta Gil-Ortega, Beatriz Merino, Beatriz Somoza, Victoria Cano, Javier de Castro, Julio Sevillano, M. Pilar Ramos, MarÃa S. Fernández-Alfonso, Mariano Ruiz-Gayo,