| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804215 | Biochimie | 2011 | 11 Pages |
Abstract
⺠The cause of hepatic lipid accumulation in peroxisome deficient hepatocytes is investigated. ⺠Steatosis develops despite increased fatty acid oxidation and reduced de novo lipid synthesis. ⺠Increased fatty acid uptake is in accordance with massive induction of CD36, a PPARα target. ⺠We challenge the assumption that PPARα activation requires de novo fatty acid synthesis in liver.
Keywords
ACCNAFLDadipose differentiation related proteinSCAPMFPacyl-CoA oxidaseADFPATP citrate lyaseACLYFGF21VLDLPEXPPARαACOX1SREBP1cCPTapoapolipoproteinnonalcoholic steatohepatitisacetyl-CoA carboxylasedocosahexaenoic acidfatty acid synthaseFatty acid oxidationNonalcoholic fatty liver diseaseFatty acid uptakeDHAfibroblast growth factor 21Fasnvery low density lipoproteinsNash HepatosteatosisPeroxinsterol regulatory element binding proteinsrebp cleavage-activating proteinMultifunctional proteinCarnitine palmitoyltransferasePeroxisome proliferator activated receptor α
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Authors
Annelies Peeters, Johannes V. Swinnen, Paul P. Van Veldhoven, Myriam Baes,