Xenobiotic metabolism and disposition in human lung: Transcript profiling in non-tumoral and tumoral tissues

► Expression profiling of genes involved in the cellular processing of xenobiotics. ► Human non-tumoral and tumoral lung tissues. ► Major differences in the metabolic capacities between bronchial mucosa and pulmonary parenchyma. ► Interindividual variability in the expression levels may lead to differences in the individual susceptibility to lung diseases. ► Overview of xenobiotic-metabolizing enzymes and transporters in non-small cell lung cancer before chemotherapy.