| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804238 | Biochimie | 2011 | 8 Pages |
Abstract
⺠Protein folding activity of the ribosome resides in the 23S rRNA of the 50S subunit. ⺠Two antiprion drugs 6AP and GA specifically arrest this function of the ribosome. ⺠These drugs competitively inhibit the substrate protein from binding to the ribosome. ⺠As a result, the yield of refolding gets compromised but the rate remains unaffected. ⺠We also estimated the time-span for interaction between the ribosome and the protein.
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Authors
Suzana Dos Reis, Yanhong Pang, Neelanjan Vishnu, Cécile Voisset, Hervé Galons, Marc Blondel, Suparna Sanyal,