| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804280 | Biochimie | 2011 | 8 Pages |
Abstract
⺠The cell-surface expressed nucleolin is a strategic target for cancer therapy. ⺠Nucleolin antagonist HB-19 pseudopeptide suppresses tumorigenesis and angiogenesis in mice. ⺠Here we show that HB-19 inhibits tumorigenicity of the highly malignant rhabdoid tumor G401 cells. ⺠Inhibitory effect of HB-19 is associated with selective down regulation of tumor-associated genes. ⺠Our results suggest that HB-19 is a potential candidate for targeted therapy of rhabdoid tumors.
Keywords
Wilms’ tumor 1GAPDHMMP-9WT1MMP-2TSP-1MidkineTIMP-1CD44sTumorigenicityThrombospondin-1Vascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Matrix metalloproteinase-9Matrix metalloproteinase-2Contact inhibitionTissue inhibitor of metalloproteinase 1Antagonist peptideglyceraldehyde-3-phosphate dehydrogenase
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Authors
Bernard Krust, Diala El Khoury, Calaiselvy Soundaramourty, Isabelle Nondier, Ara G. Hovanessian,