| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804307 | Biochimie | 2011 | 13 Pages |
Abstract
⺠2.0 Ã
crystal structure of methionyl-tRNA synthetase (MetRS) from L. major. ⺠Complex with two products, methionyladenylate and pyrophosphate, in active site. ⺠Dramatic conformational differences compared to other MetRS structures. ⺠Amino acid differences in active site compared to human homologs. ⺠Useful for structure-based design of novel anti-trypanosomal therapeutics.
Keywords
AspRSSSRLStanford Synchrotron Radiation LightsourceSCFAQPcP2LysRSMetRSCP1TrpRSPDBRMSDTLSAspartyl-tRNA synthetaseLysyl-tRNA synthetasetris(2-carboxyethyl)phosphineAminoacyl-tRNA synthetaseEthylene glycolIsoleucyl-tRNA synthetaseIleRSTranslation/Libration/ScrewTrypanosomiasisTryptophanyl-tRNA synthetaseProtozoaaaRSTCEPLeishmaniasismethionyl-tRNA synthetaseroot mean square deviationDrug targetProtein Data Bank
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Authors
Eric T. Larson, Jessica E. Kim, Frank H. Zucker, Angela Kelley, Natascha Mueller, Alberto J. Napuli, Christophe L.M.J. Verlinde, Erkang Fan, Frederick S. Buckner, Wesley C. Van Voorhis, Ethan A. Merritt, Wim G.J. Hol,