A region in the C-terminal domain of ribosomal protein SA required for binding of SA to the human 40S ribosomal subunit

► Eukaryote-specific CTD of human SA is responsible for protein binding to 40S ribosomal subunit. ► Region of the SA CTD 236-262 is required for binding of the protein to the 40S ribosomal subunits. ► Nucleotides in hairpin 40 of the 18S rRNA are involved in binding to the SA CTD.