| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804316 | Biochimie | 2011 | 4 Pages |
Abstract
⺠From ADP and arsenate, PNPase forms AMP-arsenate, which is hydrolyzed (arsenolysis). ⺠Polynucleotide phosphorylase (PNPase) does not catalyze ADP arsenolysis directly. ⺠Polynucleotide phosphorylase (PNPase) catalyzes the arsenolysis of ADP in two steps. ⺠PNPase polymerizes ADP to poly-A then cleaves poly-A with arsenate to AMP-arsenate. ⺠In presence of glutathione, the PNPase-generated AMP-arsenate is reduced to arsenite.
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Authors
Balázs Németi, Maria Elena Regonesi, Paolo Tortora, Zoltán Gregus,