Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10804394 | Biochimie | 2005 | 6 Pages |
Abstract
In addition to their ligand-mediated activation, nuclear receptor activity is finely tuned by their phosphorylation status. PPARs are phosphorylated by several kinases (PKA, PKC, MAPKs, and AMPK), which affect their activity in a ligand-dependent or -independent manner according to the isoform and cellular context. Molecular consequences are multiple, including changes in ligand affinity, DNA binding, recruitment of transcriptional cofactors, proteasome degradation⦠Finally, the physiological relevance of PPAR phosphorylation is discussed.
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Authors
Claire Diradourian, Jean Girard, Jean-Paul Pégorier,