Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10814806 | Cellular Signalling | 2015 | 34 Pages |
Abstract
There is a high frequency of tumor recurrence in non-muscle invasive bladder cancer (NMIBC) after transurethral resection and postoperative intravesical chemotherapy, however, the molecular mechanisms leading to the chemoresistance and tumor re-growth remain largely unknown. In this study, we observed a significant decrease of DAB2IP expression in high-grade and recurrent NMIBC specimens, which was negatively correlated with Twist1 expression and predicted a lower recurrence-free survival of patients. Mechanistically, DAB2IP could inhibit the phosphorylation and transactivation of STAT3, and then subsequently suppress the expression of Twist1 and its target gene P-glycoprotein, both of which were crucial for the pirarubicin chemoresistance and tumor re-growth of bladder cancer cells. Overall, this study reveals a new promising biomarker modulating the chemoresistance and tumor recurrence of NMIBC after bladder preservation surgery.
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Authors
Kaijie Wu, Bin Wang, Yule Chen, Jiancheng Zhou, Jun Huang, Ke Hui, Jin Zeng, Jianning Zhu, Kai Zhang, Lei Li, Peng Guo, Xinyang Wang, Jer-Tsong Hsieh, Dalin He, Jinhai Fan,