| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10814880 | Cellular Signalling | 2015 | 13 Pages |
Abstract
An intra-molecular interaction of a double arginine motif in the Gab1 tail with the Gab1 PH domain prevents Gab1 membrane (PIP3) binding. Membrane binding requires MAPK-dependent phosphorylation of Ser552. Gab1 membrane localisation is highly dynamic and coordinates MAPK and PI3K signalling.112
Keywords
PI3KGRB2RasGAPPIP3CrkLCrkSHP2MAPPITPLCFCSMPNIL-6PVDFHEKRas-GTPase activating proteinERKJanus kinaseMAPKSTATinterleukin-6PH domainfoetal calf serumextracellular signal regulated kinasePlasma membranephosphatidyl-inositol-3-kinasephospholipase CSignal transducer and activator of transcriptionMolecular computationMyeloproliferative neoplasmsSignal transductionGrowth factor receptor bound protein 2mitogen activated protein kinaseJAKhuman embryonic kidneyGab1
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Authors
Alexandra Wolf, René Eulenfeld, Hannes Bongartz, Wiebke Hessenkemper, Philip C. Simister, Sam Lievens, Jan Tavernier, Stephan M. Feller, Fred Schaper,