Article ID Journal Published Year Pages File Type
10814942 Cellular Signalling 2016 30 Pages PDF
Abstract
In summary, PAN induces the ERK dependent translocation of IQGAP1 into the nuclei in human podocytes which leads to the interaction of IQGAP1 with chromatin and Histone H3, and decreased interactions between IQGAP1 and slit-diaphragm proteins. Therefore, IQGAP1 may have a role in podocyte gene regulation in glomerular disease.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Nuclear translocation of IQGAP1 protein upon exposure to puromycin aminonucleoside in cultured human podocytes: ERK pathway involvement
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