Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10814942 | Cellular Signalling | 2016 | 30 Pages |
Abstract
In summary, PAN induces the ERK dependent translocation of IQGAP1 into the nuclei in human podocytes which leads to the interaction of IQGAP1 with chromatin and Histone H3, and decreased interactions between IQGAP1 and slit-diaphragm proteins. Therefore, IQGAP1 may have a role in podocyte gene regulation in glomerular disease.
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Authors
Claire Rigothier, Moin Ahson Saleem, Chantal Bourget, Peter William Mathieson, Christian Combe, Gavin Iain Welsh,