Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10814990 | Cellular Signalling | 2016 | 26 Pages |
Abstract
These results suggest a novel mechanism whereby elevated TGF-β/Smad3 stimulates the secretion of canonical Wnts which in turn enhances SMC proliferation through β-catenin stabilization. This crosstalk between TGF-β/Smad3 and Wnt/β-catenin canonical pathways provides new insights into the pathophysiology of vascular SMCs linked to intimal hyperplasia.
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Authors
Daniel M. DiRenzo, Mirnal A. Chaudhary, Xudong Shi, Sarah R. Franco, Joshua Zent, Katie Wang, Lian-Wang Guo, K. Craig Kent,