| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815009 | Cellular Signalling | 2016 | 15 Pages |
Abstract
Interestingly, the Alzheimer's amyloid precursor protein (APP), forms a trimeric complex composed of PP1 and Fe65, with PP1 having the capacity to dephosphorylate APP at Thr668 residue. The emerging consensus appears to be that PP1 containing complexes are crucial in regulating signaling events underlying neuropathological conditions.
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Authors
Filipa Martins, Sandra Rebelo, Mariana Santos, Cândida Zita Cotrim, Edgar F. da Cruz e Silva, Odete A.B. da Cruz e Silva,