Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10815020 | Cellular Signalling | 2016 | 10 Pages |
Abstract
Protein neddylation is essential for the viability of most organisms and is widely involved in the regulation of immunity, DNA damage and repair, cell signaling and cell cycle. Unlike RING-type neddylation ligases, HECT-type neddylation ligase remains less defined. Here, we show that Itch is a novel HECT-type neddylation E3 ligase and we identify JunB as a substrate of Nedd8 modification by Itch. JunB neddylation attenuates its transcriptional activity. In addition, JunB neddylation mediated by Itch promotes its ubiquitination-dependent degradation. Therefore, these findings define a new HECT-type neddylation ligase and its neddylation substrate.
Keywords
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Authors
Haiwen Li, Heng Zhu, Yang Liu, Fuchu He, Ping Xie, Lingqiang Zhang,