Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10815099 | Cellular Signalling | 2014 | 7 Pages |
Abstract
The E3 Ubiquitin ligase TRIM50 promotes the formation and clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction, a tubulin specific deacetylase that regulates microtubule-dependent aggresome formation. In this report we showed that TRIM50 is a target of HDAC6 with Lys-372 as a critical residue for acetylation. We identified p300 and PCAF as two TRIM50 acetyltransferases and we further showed that a balance between ubiquitination and acetylation regulates TRIM50 degradation.
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Authors
Carmela Fusco, Lucia Micale, Bartolomeo Augello, Barbara Mandriani, Maria Teresa Pellico, Pasquelena De Nittis, Alessia Calcagnì, Maria Monti, Flora Cozzolino, Piero Pucci, Giuseppe Merla,