Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10815273 | Cellular Signalling | 2014 | 10 Pages |
Abstract
The review summarizes recent advances in characterization of adult epithelial stem cells in the gut. We mainly focus on discoveries related to molecular mechanisms regulating the output of the Wnt pathway. Moreover, we present novel experimental approaches utilized to investigate the epithelial cell signaling circuitry in vivo and in vitro. Pivotal aspects of tissue homeostasis are often deduced from studies of tumor cells; therefore, we also discuss some latest results gleaned from the deep genome sequencing studies of human carcinomas of the colon and rectum.
Keywords
TAZAXINCBCMSIFAPβ-TrCPGSK3APCMSStranscriptional co-activator with PDZ-binding motifOrganoidsCSCsR-spondinRSPOLRPLgrRNF43LRCsLEF/TCFBeta-transducin repeat containing proteinISCsadenomatous polyposis coliDkkdickkopfYAPMicrosatellite instabilityTumorGastrointestinalcrypt base columnarColorectal cancercolorectal carcinomaintestinal stem cellsLabel-retaining cellsCancer stem cellsMouse modelsBMPyes-associated proteinlow density lipoprotein receptor-related proteinAxis inhibition proteinbone morphogenic proteinfamilial adenomatous polyposisCRCGutglycogen synthase kinase 3
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Authors
Michaela Krausova, Vladimir Korinek,