| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815295 | Cellular Signalling | 2014 | 9 Pages |
Abstract
Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca2 + and other intracellular signals. In addition to the transmembrane isoforms, one AC is soluble and exhibits distinct regulation. In this review, the basic structure, regulation and physiological roles of ACs in the digestive system are discussed.
Keywords
EGFGEFEpacNKCCPKCCFTRGPCRCCKpKaVIPGTPG protein coupled receptorsadenylyl cyclasecystic fibrosis transmembrane regulatorGDPtumor necrosis factor-αIntestineepidermal growth factorSalivary glandguanine nucleotide exchange factorTNF-αStomachNitric oxideExocrine PancreasExchange protein directly activated by cAMPcAMP-dependent protein kinase AProtein kinase CVasoactive intestinal polypeptideLivercholecystokininGuanosine triphosphateguanosine diphosphate
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Authors
Maria Eugenia Sabbatini, Fred Gorelick, Shannon Glaser,