Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10815310 | Cellular Signalling | 2014 | 16 Pages |
Abstract
On the other hand, purinergic ligand exclusively recruited the GRK5 subtype, and induced, via a G protein-independent/β-arrestin-dependent mechanism, a receptor/β-arrestin stable association, slower and sustained ERK stimulation and marginal CREB activation. These results show that purinergic and cysLT ligands, through the recruitment of specific GRK isoforms, address distinct intracellular pathways, most likely reinforcing the same final response. The identification of these mechanisms and players controlling GPR17 responses during OPC differentiation could be useful to identify new targets in demyelination diseases and to develop new therapeutical strategies.
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Authors
Simona Daniele, Maria Letizia Trincavelli, Marta Fumagalli, Elisa Zappelli, Davide Lecca, Elisabetta Bonfanti, Pietro Campiglia, Maria P. Abbracchio, Claudia Martini,