| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815326 | Cellular Signalling | 2013 | 7 Pages |
Abstract
⺠This is the first observation of oscillations in MAPK/PI3K signalling in breast cancer cells. ⺠A combined experimental and computational approach reveals likely regulatory models. ⺠These include receptor overexpression, transcriptional control, and pathway crosstalk. ⺠The core transcriptional regulatory motif responsible for oscillations is enriched for DUSPs. ⺠The study highlights the benefits of using a combined theoretical and experimental approach.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Huizhong Hu, Alexey Goltsov, James L. Bown, Andrew H. Sims, Simon P. Langdon, David J. Harrison, Dana Faratian,