Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells

Article ID	Journal	Published Year	Pages	File Type
10815330	Cellular Signalling	2013	8 Pages	PDF

Abstract

âº Molecular signaling of mAR activation in colon cancer cells was elucidated. âº A novel signaling pathway triggering early actin reorganization is presented. âº FAK and mTOR/p70S6K activation triggers PAK1. âº PAK1 governs the early actin polymerization. âº Paxillin and Rho/ROCK signaling are not involved.

Keywords

PI3K Actin reorganization IAR PAK1 Phosphatidylinositide-3-kinase p70S6K PFA TAC MAR FAK mTOR HSA DEX p21-activated kinase 1 S6 kinase human serum albumin Dexamethasone mammalian target of rapamycin paraformaldehyde focal adhesion kinase

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells

Authors

Shuchen Gu, Michalis Kounenidakis, Eva-Maria Schmidt, Divija Deshpande, Saad Alkahtani, Saud Alarifi, Michael Föller, Konstantinos Alevizopoulos, Florian Lang, Christos Stournaras,