Article ID Journal Published Year Pages File Type
10815333 Cellular Signalling 2013 5 Pages PDF
Abstract
► Syndecan-4 dependent PKCα activation is necessary for PDK1 recruitment to the rafts. ► Syndecan-4/PKC-alpha also recruits PAKL1/PAK2. ► The presence of PDK1/PAK1/PAK2 is required for Akt activation. ► These results place syndecan-4a t the center of Akt signaling regulation.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Syndecan 4 regulation of PDK1-dependent Akt activation
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