| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815335 | Cellular Signalling | 2013 | 13 Pages |
Abstract
⺠Mechanisms of enhancing cAMP-stimulated CREB-dependent transcription by lithium. ⺠Lithium does not compete with magnesium for binding at the CREB-bZip. ⺠Lithium strengthens the formation of a CBP-CREB-CRTC ternary complex. ⺠Lithium promotes oligomerization of CRTC, required for CRTC-CREB interaction.
Keywords
GSTGSK3pKabZIPCBPCRTCHGFTORCHIT-T15Basic region-leucine zipperkinase-inducible domainSCEDBDEMSAqPCRCRECREBLithiumBDNFcAMPElectrophoretic mobility shift assaychromatin immunoprecipitationTADKidProtein–protein interactionTranscriptional regulationDNA-Binding Domaintransactivation domainHepatocyte growth factorbrain derived neurotrophic factorcAMP-response elementquantitative real-time PCRCREB-binding proteincAMP-response element binding proteinprotein kinase ACHiPglutathione S-transferaseglycogen synthase kinase 3
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Authors
Annette Heinrich, Anne Sophie von der Heyde, Ulrike Böer, Do Thanh Phu, Mladen Tzvetkov, Elke Oetjen,