Article ID Journal Published Year Pages File Type
10815339 Cellular Signalling 2013 9 Pages PDF
Abstract
► The JNK pathway is a novel mediator of sestrin 2 expression. ► C-Jun is involved in the regulation of sestrin 2 transcription. ► JNK/sestrin 2 is required for excisanin A or serum deprivation-induced autophagy. ► Sestrin 2-mediated autophagy promotes cell death induced by excisanin A.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Upregulation of sestrin 2 expression via JNK pathway activation contributes to autophagy induction in cancer cells
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