Article ID Journal Published Year Pages File Type
10815343 Cellular Signalling 2013 8 Pages PDF
Abstract
► First report of a new GEF for Ras that happens to be a phospholipase. ► PLD2-GEF acting on Ras follows faster kinetics than other substrates (Rac2). ► Highly metastatic cancer cells have both high levels of Ras and PLD2-“GEF” activity. ► Single point mutations on GEF activity defined in this study for the first time. ► New GEF mutants slow down the rate of growth of breast cancer cells.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras
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