Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells

Article ID	Journal	Published Year	Pages	File Type
10815344	Cellular Signalling	2013	8 Pages	PDF

Abstract

âº Ursolic acid induces ER stress response in cultured bladder cancer T24 cells. âº Salubrinal inhibits ursolic acid-induced ER stress response. âº Salubrinal or PERK silencing inhibited ursolic acid-induced cytotoxic effects. âº Ursolic acid induces IRE1-TRAF2-ASK1 complex formation to activate ASK1-JNK.

Keywords

ACC double-stranded RNA-activated protein kinase (PKR)-like ER kinase ASK1 ATF6 eIF2α IRE1 AMPK Jnk AMP-activated protein kinase C/EBP homologous protein c-Jun N-terminal kinase MTT RNAi inositol-requiring enzyme 1 ER stress acetyl-CoA carboxylase Ursolic acid Enzyme-linked immunosorbent assay ELISA CHOP apoptosis signal regulating kinase 1 activating transcription factor 6 PERK