Article ID Journal Published Year Pages File Type
10815350 Cellular Signalling 2013 18 Pages PDF
Abstract
► NAP isolated from SF is found in tumor cells and human breast cancer biopsies. ► NAP is a permeability factor inducing angiogenesis in cell-based and in vivo assays. ► Functional mAb against NAP abrogated proangiogenic properties of NAP. ► NAP is a substrate for p38 MAPK for VEGF signaling in tumor cells. ► Angiogenic signaling by NAP involves JNK besides upregulation of VEGF and VEGFR genes.
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