Article ID Journal Published Year Pages File Type
10815356 Cellular Signalling 2013 13 Pages PDF
Abstract
► High glucose induces endothelial dysfunction via Nox4/ROS/CIKS/NF-κB/AP-1. ► Targeting CIKS blunts HG induced adhesion molecule and cytokine expression. ► AGEs, oxLDL and AOPPs induce CIKS-dependent endothelial dysfunction. ► Type 1 diabetic animals express high levels of CIKS in the aorta in vivo. ► CIKS is a novel therapeutic target in diabetic vascular complications.
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