Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10815379 | Cellular Signalling | 2015 | 10 Pages |
Abstract
Apoptosis is a prominent characteristic in the pathogenesis of liver disease. The mechanism of hepatic apoptosis is not well understood. Hepatic apoptosis alters relative levels of nuclear factors such as Foxa2, NF-κB, C/EBPβ, and p53. Regulation of nuclear factors modulates the degree of hepatic apoptosis and the progression of liver disease. Nuclear factors have distinctive mechanisms to mediate hepatic apoptosis. The modification of nuclear factors is a novel therapeutic strategy for liver disease as demonstrated by pre-clinical models and clinical trials.
Keywords
IRSMCD dietGSTSTAT5XIAPPSCiNOSFOXA2FOXM1LXRαMPTPBCMTPPEPCKTLRPGC-1αIAPp53CREBPPAR-γNF-κBCDKEMSAForkhead box protein A2peroxisome proliferator-activated receptor γ coactivator 1αTumor necrosis factor (TNF)-related apoptosis-inducing ligandHNF6NAFLDTNFαHepatic apoptosisSREBP-1cCYP7A1C/EBPαc/ebpβcAMPdouble-stranded DNADNAIgf1ROSALDcyclic adenosine 3′,5′-monophosphatechromatin immunoprecipitation assayElectrophoretic mobility shift assayalpha-fetoproteinER stressEndoplasmic reticulum stressdeoxyribonucleic acidmitochondrial permeability transitioninsulin receptor substratealcoholic liver diseasenon-alcoholic fatty liver diseaseterminal deoxynucleotidyl transferase dUTP nick-end labelingtriglycerideAFPEnzyme-linked immunosorbent assayELISAChIP assaytumor necrosis factor-alphaTUNELToll-like receptorforkhead box M1Colorectal carcinogenesisnatural killer T cellsNKT cellsinducible nitric oxide synthasePrimary biliary cirrhosisNuclear factorsinsulin-like growth factor 1nuclear factor kappa-light-chain-enhancer of activated B cellssignal transducer and activator of transcription 5phosphoenolpyruvate carboxykinaseTRAILinhibitors of apoptosisprotein 53X-linked Inhibitor of Apoptosis ProteinSterol regulatory element binding protein 1cMicrosomal triacylglycerol transfer proteincAMP response element-binding proteinliver X receptor alphaCRCPrimary sclerosing cholangitiscyclin-dependent kinasesPeroxisome proliferator-activated receptor gammaglutathione S-transferasesReactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Kewei Wang,