Article ID Journal Published Year Pages File Type
10815403 Cellular Signalling 2012 10 Pages PDF
Abstract
► Metastatic TCC cells acquire epithelial phenotypes after bone re-colonization. ► PI3K/Akt targets GSK3β/β-catenin to modulate ZEB1 expression and cell invasion. ► ZEB1 drives EMT and controls TCC cell adhesion, migration and invasion. ► Elevated ZEB1 correlates with EMT and clinical prognosis in muscle-invasive TCC.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Authors
, , , , , , , , , , , ,