Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10815403 | Cellular Signalling | 2012 | 10 Pages |
Abstract
⺠Metastatic TCC cells acquire epithelial phenotypes after bone re-colonization. ⺠PI3K/Akt targets GSK3β/β-catenin to modulate ZEB1 expression and cell invasion. ⺠ZEB1 drives EMT and controls TCC cell adhesion, migration and invasion. ⺠Elevated ZEB1 correlates with EMT and clinical prognosis in muscle-invasive TCC.
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Authors
Kaijie Wu, Jinhai Fan, Linlin Zhang, Zhongyun Ning, Jin Zeng, Jiancheng Zhou, Lei Li, Yule Chen, Tingting Zhang, Xinyang Wang, Jer-Tsong Hsieh, Dalin He,