| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815404 | Cellular Signalling | 2012 | 8 Pages |
Abstract
⺠Leptin increased intracellular Ca2 +and Na+ concentrations and decreased Na+/K+ ATPase ⺠Leptin produced calcineurin activation and translocation of NFAT into nuclei ⺠Calcineurin activation was dependent on both Ca2 + and RhoA Ca2 +-independent activity ⺠Calcineurin regulates p38 MAPK as a key factor in the hypertrophic response ⺠We propose a novel mechanism for calcineurin regulation in leptin-induced hypertrophy
Keywords
PBSRho-associated, coiled-coil containing protein kinaseFBSMCIPFK-506NFATRhoA/ROCKNKADTTKB-R7943NCXRhoAHBSSBSAERK1/2MAPKp38 MAP kinaseras homolog gene family, member Abovine serum albuminTacrolimusdithiothreitolIntracellular sodiumfetal bovine serumNuclear Factor of Activated T CellsLeptinPhosphate-buffered salineHank's balanced salt solutionCardiomyocyte hypertrophymitogen activated protein kinaseIntracellular calciumCalcineurinRock
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Authors
Venkatesh Rajapurohitam, Farzad Izaddoustdar, Eduardo Martinez-Abundis, Morris Karmazyn,