| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815410 | Cellular Signalling | 2012 | 12 Pages |
Abstract
⺠RA activation of Wnt-β-catenin signalling induces F9 cells into primitive endoderm. ⺠A burst of ROS precedes and is necessary for this differentiation event. ⺠H2O2 affects β-catenin-dependent Tcf-Lef transcription and induces differentiation. ⺠The Nox1-4 and Duox 2 genes encoding NADPH oxidases are RA-responsive. ⺠RA-induced differentiation is affected by Nox activity inhibitors.
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Authors
Jason W.H. Wen, Jason T.K. Hwang, Gregory M. Kelly,