Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75NTR and Î±9Î²1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model

Article ID	Journal	Published Year	Pages	File Type
10815413	Cellular Signalling	2012	11 Pages	PDF

Abstract

âº NGF-induced ERK1/2 phosphorylation through p75NTR and Î±9Î²1 integrin in C2C12 cells. âº Î±9Î²1 integrin is important in NGF signaling in the skeletal muscle lacking trkA. âº Autocrine trophic and myoprotective effects were mediated by NGF signaling. âº A novel NGF-induced, receptors cross-talk model is proposed for skeletal muscle.

Keywords

p75NTR K252a MyoD PD98059 C2C12 ADAM12 PC12 trkA OGD NGF EC50 GAPDH ERK1/2 Reoxygenation ELISA Enzyme-linked immunosorbent assay C2C12 cells Skeletal muscle effective concentration 50%nerve growth factor lactate dehydrogenase LDH Oxygen-glucose deprivation glyceraldehyde 3-phosphate dehydrogenase

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75NTR and Î±9Î²1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model

Authors

Keren Ettinger, Shimon Lecht, Hadar Arien-Zakay, Gadi Cohen, Shlomit Aga-Mizrachi, Nurit Yanay, H. Uri Saragovi, Hinyu Nedev, Cezary Marcinkiewicz, Yoram Nevo, Philip Lazarovici,