FK506 induces endothelial dysfunction through attenuation of Akt and ERK1/2 independently of calcineurin inhibition and the caspase pathway

Article ID	Journal	Published Year	Pages	File Type
10815427	Cellular Signalling	2013	8 Pages	PDF

Keywords

TMA HUVEC eNOS ERK FKBP PKC GAPDH shRNA bFGF Nuclear factor of activated T cell Three-dimensional NFAT n.s.FK506 zVAD EGF WST-8 DMSO ERK1/2 MAPK short hairpin RNA Akt Endothelial dysfunction CSA analysis of variance ANOVA Dimethylsulfoxide Human umbilical vein endothelial cells cyclosporin A epidermal growth factor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)basic fibroblast growth factor not significant thrombotic microangiopathy FK506-binding protein Protein kinase C mitogen-activated protein kinase caspase Calcineurin extracellular-regulated kinase glyceraldehyde-3-phosphate dehydrogenase

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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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FK506 induces endothelial dysfunction through attenuation of Akt and ERK1/2 independently of calcineurin inhibition and the caspase pathway

Authors

Ryoji Eguchi, Shuji Kubo, Toshiro Ohta, Kazuhiro Kunimasa, Masaya Okada, Hiroya Tamaki, Kazuhiko Kaji, Ichiro Wakabayashi, Yoshihiro Fujimori, Hiroyasu Ogawa,