| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815485 | Cellular Signalling | 2014 | 8 Pages |
Abstract
Our data show that canonical Wnt signaling is able to skew TGF-β signaling towards dominant signaling via the ALK1/Smad 1/5/8 pathway, which reportedly leads to chondrocyte hypertrophy. In this way canonical Wnts and WISP1, which we found to be increased during experimental osteoarthritis, may contribute to osteoarthritis pathology.
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Authors
Martijn H. van den Bosch, Arjen B. Blom, Peter L. van Lent, Henk M. van Beuningen, Esmeralda N. Blaney Davidson, Peter M. van der Kraan, Wim B. van den Berg,