Upregulation of HIF-2Î± induced by sorafenib contributes to the resistance by activating the TGF-Î±/EGFR pathway in hepatocellular carcinoma cells

Article ID	Journal	Published Year	Pages	File Type
10815491	Cellular Signalling	2014	10 Pages	PDF

Keywords

Hypoxia-inducible factor-2α CHX HIF-1α ARNT qRT-PCR ERK phosphorylated ERK1/2 HIF-2α FITC PHD VEGFR DMEM EGFR STAT3 p-STAT3 CCK-8 Tgf-α DMSO HCC MAPK Dulbecco's modified Eagle's medium p-Akt p-ERK1/2 aryl hydrocarbon receptor nuclear translocator standard deviation transforming growth factor-α analysis of variance ANOVA Dimethyl sulfoxide Sorafenib cycloheximide cell counting kit-8 hypoxia-inducible factor-1α Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)phosphorylated Akt phosphorylated phosphorylated STAT3 fluorescein isothiocyanate signal transducer and activator of transcription 3 Hypoxia quantitative reverse-transcription polymerase chain reaction mitogen-activated protein kinase Prolyl hydroxylase Hepatocellular carcinoma extracellular signal-regulated kinase VEGF receptor platelet-derived growth factor receptor Epidermal growth factor receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Upregulation of HIF-2Î± induced by sorafenib contributes to the resistance by activating the TGF-Î±/EGFR pathway in hepatocellular carcinoma cells

Authors

Dali Zhao, Bo Zhai, Changjun He, Gang Tan, Xian Jiang, Shangha Pan, Xuesong Dong, Zheng Wei, Lixin Ma, Haiquan Qiao, Hongchi Jiang, Xueying Sun,