Article ID Journal Published Year Pages File Type
10815532 Cellular Signalling 2012 7 Pages PDF
Abstract
► Twist1 is aberrantly expressed in ALK + ALCL, a type of T-cell lymphoid malignancy. ► Twist1 expression in ALK + ALCL cells can be attributed to the NPM-ALK/STAT3 signaling axis. ► Twist1 regulates the invasiveness of ALK + ALCL. ► The increase of invasiveness in ALK + ALCL cells mediated by Twist1 is linked to AKT and p66Shc. ► Knockdown of Twist1 sensitizes ALK + ALCL cells to Crizotinib, a tyrosine kinase inhibitor.
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