| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815532 | Cellular Signalling | 2012 | 7 Pages |
Abstract
⺠Twist1 is aberrantly expressed in ALK + ALCL, a type of T-cell lymphoid malignancy. ⺠Twist1 expression in ALK + ALCL cells can be attributed to the NPM-ALK/STAT3 signaling axis. ⺠Twist1 regulates the invasiveness of ALK + ALCL. ⺠The increase of invasiveness in ALK + ALCL cells mediated by Twist1 is linked to AKT and p66Shc. ⺠Knockdown of Twist1 sensitizes ALK + ALCL cells to Crizotinib, a tyrosine kinase inhibitor.
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Authors
Jingdong Zhang, Peng Wang, Fang Wu, Matthew Li, David Sharon, Robert J. Ingham, Mary Hitt, Todd P. McMullen, Raymond Lai,