| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815542 | Cellular Signalling | 2012 | 7 Pages |
Abstract
⺠TNFα induces phospho-MAPKs and upregulates MKP-1 in a temporally-distinct manner. ⺠TNFα-induced MKP-1 mRNA stability is regulated by the p38 MAPK pathway. ⺠Without MKP-1, MAPK signaling and cytokine secretion by ASM is unrestrained. ⺠The MAPK deactivator MKP-1 acts in a negative feedback manner. ⺠TNFα controls pro-inflammatory cellular signaling in ASM cells via MKP-1.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Melanie Manetsch, Wenchi Che, Petra Seidel, Yang Chen, Alaina J. Ammit,