| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815543 | Cellular Signalling | 2012 | 8 Pages |
Abstract
⺠Stimulation of Gαq, Gα11, Gα14 and Gα15 induced rapid PKD1 activation via PKC. ⺠Gαq, Gα11, Gα14 and Gα15 promoted membrane translocation of PKD. ⺠Gαq but not other Gα induced sustained PKD activation via a PKC-independent pathway. ⺠The Gαq-selective P multocida toxin induced biphasic PKD activation in 3T3 cells. ⺠Our results reveal a non-redundant function of Gαq and Gα11 on PKD activation.
Keywords
PAGEAEBSFPKC4-(2-aminoethyl)-benzenesulfonyl fluoride hydrochloridePMTPKDPLCGPCRCaMKRFPALF4GFPPDBuPasteurella multocida toxinGαCa2 +/calmodulin-dependent protein kinaseDMEMAlF4−PBSBSADulbecco's modified Eagle Mediumbovine serum albuminpolyacrylamide gel electrophoresisdiacylglycerolDAGphospholipase CAluminum fluoridePhosphate-buffered salineenhanced green fluorescent proteinred fluorescent proteinprotein kinase DProtein kinase CG protein-coupled receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Richard T. Waldron, Giulio Innamorati, M. Eugenia Torres-Marquez, James Sinnett-Smith, Enrique Rozengurt,