Redox signaling loops in the unfolded protein response

Article ID	Journal	Published Year	Pages	File Type
10815555	Cellular Signalling	2012	8 Pages	PDF

Abstract

âº ER maintains protein redox balance. âº ER stress triggers the UPR. âº Redox signalling modulates the UPR.

Keywords

Trx ERSE IP3R1 Muc2 MAP kinase kinase kinase GADD34 GRP94 AGR2 MAP kinase kinase PTP1B PDI BI-1 ASK1 GRP78 Kelch-like ECH-associated protein-1 ATF6 eIF2α TCPTP Nrf2-ECH homology sXBP1 ERQC inositol-requiring protein-1 ER oxidoreductin 1 TNF EDEM1 NEH TRAF2 Ero1 Nuclear factor-E2-related factor-2 MAPKKK coat protein complex II MAPKK CANX cap ‘n’ collar XBP1 GSSG GSH Nrf2 Crt Hsp ERAD CSE ATF4 Jnk UPR IRE1 CNC EGF PI3K BiP keap1 C/EBP-homologous protein c-Jun N-terminal kinase cystathionine γ-lyase MAPK Small interfering RNA ROS siRNA ER stress ER-Associated Degradation CHOP thioredoxin X-box binding protein-1 RIDD endoplasmic reticulum epidermal growth factor antioxidant responsive element tumor necrosis factor phosphoinositide-3-kinase activating transcription factor-4 activating transcription factor-6 MHC major histocompatibility complex bax inhibitor-1 Mucin 2 map ARE Unfolded protein response 78 kDa glucose-regulated protein protein disulfide isomerase mitogen-activated protein protein kinase RNA-like ER kinase heat-shock protein PERK reduced glutathione calreticulin calnexin ER quality control COPII MAP kinase Apoptosis signal-regulating kinase-1 Anterior gradient 2 oxidized glutathione Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Redox signaling loops in the unfolded protein response

Authors

Arisa Higa, Eric Chevet,