Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation

Article ID	Journal	Published Year	Pages	File Type
10815568	Cellular Signalling	2012	8 Pages	PDF

Abstract

âº MEF2 and mAKAP interact directly in C2C12 cells during myogenic differentiation. âº This interaction is required for transcriptional activity of MEF2. âº Disruption of the interaction halts myogenic differentiation. âº Disruption of the interaction blunts expression of MEF2 target genes.

Keywords

MEF2 PDE4D3 AKAP Myogenesis C2C12 HIF-1α pKa GFP NFAT ERK5 Skeletal muscle differentiation hypoxia inducible factor 1α nuclear factor of activated T-cells myocyte enhancer factor 2 Scaffold protein green fluorescent protein protein kinase A mAKAP

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation

Authors

Maximilian A.X. Vargas, Jennifer S. Tirnauer, Nicole Glidden, Michael S. Kapiloff, Kimberly L. Dodge-Kafka,