| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815570 | Cellular Signalling | 2012 | 11 Pages |
Abstract
⺠Cyclic AMP rapidly initiates a neuroendocrine phenotype in prostate cells. ⺠PKA is necessary and sufficient for initiation of the neuroendocrine phenotype. ⺠Inhibition of PKA-mediated phosphorylation of RhoA on Ser188 blocks the effect.
Keywords
EpacCREBPSAforskolinbFGFRhoAERKFskpKaRACK1NGFcyclic AMPcAMPPCAProstate cancerepithelial cellsneuroendocrinenerve growth factorbasic fibroblast growth factorprostate-specific antigencAMP response element binding proteinExchange protein directly activated by cAMPcAMP-dependent protein kinaseRho-associated protein kinaseextracellular signal-regulated kinaseRock
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Authors
Sarah E. Jones, Timothy M. Palmer,