Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptors

► Kinin B1 and B2 receptors are important in normal and pathological conditions. ► We tested kinin derivatives containing C-terminal Lys instead of the native Arg. ► Lys9-bradykinin and Lys10-kallidin effectively activated both B1 and B2 receptors. ► The Lys-kinin derivatives showed biased agonism for B2 receptor activation of ERK1/2. ► Dual activators of B1and B2 receptors might be therapeutically useful.