Article ID Journal Published Year Pages File Type
10815592 Cellular Signalling 2012 6 Pages PDF
Abstract
► Metformin repress Txnip transcription via AMPK-depedent and independent mechanisms. ► Metformin reduce Txnip expression by inhibiting OXPHOS and inducing glycolysis. ► Txnip might be a mediator for metformin's antidiabetic function.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
A potential mechanism of metformin-mediated regulation of glucose homeostasis: Inhibition of Thioredoxin-interacting protein (Txnip) gene expression
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