Peroxisome proliferator-activated receptor-Î³ cross-regulation of signaling events implicated in liver fibrogenesis

Article ID	Journal	Published Year	Pages	File Type
10815665	Cellular Signalling	2012	10 Pages	PDF

Abstract

âº PPARÎ³ is a pivotal molecular in hepatic stellate cell activation and liver fibrosis. âº PPARÎ³ interacts with signal pathways mediated by growth factors and adipokines. âº PPARÎ³ modulates apoptosis and senescence implicated in liver fibrogenesis. âº These molecular insights update PPARÎ³ biology and understanding of hepatic fibrosis. âº Drug targets for antifibrotic therapy may derive from PPARÎ³-mediated mechanisms.

Keywords

ObR peroxisome-proliferator activated receptor NF-κB-inducing kinase JAK2 TLR EGR-1 TGF-β SA-β-gal PDGF TNF HGF ECM AdipoR SMP30 CHB AP1 LXR-α peroxisome proliferator response elements TRAIL-R TβR NIK Janus Kinase 2 PPAR HSC liver X receptor-α Jnk PI3K NF-κB SREBP-1c STAT3 Sirt1 AMPK CTGF ERK C/EBP c-Jun N-terminal kinase MAPK senescence-associated β-galactosidase PPRE transforming growth factor-β transforming growth factor-β receptor Toll-like receptor Hepatic stellate cell Hepatocyte growth factor Connective tissue growth factor platelet-derived growth factor tumor necrosis factor nuclear factor-κB phosphatidylinositol-3-kinase Liver fibrosis Extracellular matrix signal transducer and activator of transcription 3 cross-regulation Signal transduction chronic hepatitis B early growth response-1 CCAAT/enhancer binding protein activator protein 1 senescence marker protein 30 5′-AMP-activated protein Kinase mitogen-activated protein kinase Cidea extracellular signal-regulated kinase adiponectin receptor death receptor Peroxisome proliferator-activated receptor-γ