| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815667 | Cellular Signalling | 2012 | 9 Pages |
Abstract
⺠Vav1 sustains the agonist-induced maturation of APL-derived cells. ⺠Vav1 is responsible of GEF-independent modifications of cell and nuclear morphology. ⺠Vav1 drives inside the nucleus molecules involved in mRNA production and stability. ⺠Vav1 may be a target for anti-cancer strategies in hematological malignancies.
Keywords
NFATGuanosine exchange factorVav1PIP2PIP3GEFLICphorbol 12-myristate 13-acetatePAKAP-1NF-κBAPLatRAPMAPhosphatidylinositol 4-phosphateall-trans retinoic acidMyeloid differentiationactin cytoskeletonnuclear factor of activated T-cellsnuclear factor κBphosphatidylinositol 4, 5-bisphosphateAcute promyelocytic leukemiaCell nucleusmRNA processingactivator protein-1PiP
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Authors
Valeria Bertagnolo, Federica Brugnoli, Silvia Grassilli, Ervin Nika, Silvano Capitani,