| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10815669 | Cellular Signalling | 2012 | 8 Pages |
Abstract
⺠The inositol 5 phosphatase SHIP1 is localized in nuclear puncta of Jurkat cells. ⺠SHIP1 partially co-localizes with FLASH, a multifunctional nuclear protein. ⺠Nuclear and cytoplasmic SHIP1 have the same specific enzymatic activity. ⺠Nuclear import of SHIP1 is mediated by two canonical nuclear localization signals. ⺠Inactivation of each NLS inhibited nuclear import and reduced the proliferation.
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Authors
Marcus M. Nalaskowski, Anja Metzner, Maria A. Brehm, Sena Labiadh, Helena Brauer, Nicole Grabinski, Georg W. Mayr, Manfred Jücker,